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KMID : 0614620000350060732
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Korean Journal of Gastroenterology
2000 Volume.35 No. 6 p.732 ~ p.745
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Expression of Carbohydrate Antigens in Gastric Epithelial Dysplasia and Gastric Carcinoma by Immunohistochemistry
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Kam Dong-Ho
Choi Seok-Reyol
Han Sang-Young
Kim Jong-Seong
Jeong Jin-Sook
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Abstract
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Background/Aims : The transition from intestinal metaplasia to adenocarcinoma is characterized by further qualitative and quantitative alterations of mucin-related carbohydrate antigens. The aims of this study were to examine expression patterns of mucin-related carbohydrate antigens, to investigate the relationship between the expression pattern and prognostic factors, and to evaluate the usefulness of the expression patterns in assessing the progression of gastric carcinoma.
Methods : Immunohistochemical studies of 3 carbohydrate antigens (Tn, sTn, sLeχ) were performed for 63 gastric carcinoma tissues (EGC:23 cases, AGC:40 cases) and 54 gastric epthelial dysplasia tissues obtained from January 1997 to December 1997.
Results : The carbohydrate antigens were significantly expression in advanced gastric cancer. By the results of immunohistochemistry for Tn and sTn antigens, distribution and intensity of staining were also significantly increased in progression to advanced gastric cancer. Especially, dysplastic lesions had the tendency to show supranuclear Golgi staining pattern, and carcinomas showed diffuse cytoplasmic pattern or luminal border pattern of neoplastic glands. The expression of Tn antigen was significantly increased in carcinomas with deep invasion. The expression of Tn and
sLeχ antigens were significantly increased in advanced gastric cancer with lymph node metastasis.
Conclusions : These results suggest that the expression patterns of the mucin-related carbohydrate antigens may be correlated with prognostic factors and predict the progression from gastric epithelial dysplasia to advanced gastric cancer.
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KEYWORD
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Gastric epithelial dysplasia, Gastric carcinoma, Tn, sTn, sLeχ,
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